Scientific Studies Show the Benefits and the Safety of the Ingredients Used in RG-Cell® Concentrated Restorative Skin Serum
There are an incredible number of studies that have shown RG-Cell®’s carefully selected ingredients to be both safe and effective for improving the condition and visibly reversing the age of your skin. No other product on the market uses a naturally derived combination of ingredients – scientifically proven to support our claims.
HUMAN OLIGOPEPTIDE-1 (EGF) Epidermal growth factor – Stimulates new cell growthObtained by genetic engineering technology (microbial recombinant) totally identical to natural EGF, known as a “BEAUTYFACTOR”, boosts and regulates stem cell proliferation. Because of its recombinant technology it is totally safe unlike other products that use human derived stem cells. The discovery of EGF won a Nobel Prize in Physiology and Medicine in 1986. Rh-EGF has now become the first choice to eliminate wrinkle without the adverse reactions of Botox Injection.
- J Drugs Dermatol. 2012 May;11(5):613-20.
Improved texture and appearance of human facial skin after daily topical application of barley produced, synthetic, human-like epidermal growth factor (EGF) serum
- J Cosmet Laser Ther. 2010 Feb;12(1):14-20.
Combination of physiologically balanced growth factors with antioxidants for reversal of facial photo damage
- Am J Physiol Cell Physiol. August 17, 2005, doi: 10.1152/ajpcell.00142.2005
EGF stimulates proliferation of mouse embryonic stem cells: involvement of Ca2+ influx and p44/42 MAPKs
- Biol Cell. 2005 Mar;97(3):173-83.
Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing.
- Lancet. 2001 Sep 29;358(9287):1067-8.
Dedifferentiation of epidermal cells to stem cells in vivo
- Molecular and Cellular Biology Vol. 9. No. 7; 2771-2778; 0270-7306/89/072771-08$02.00/0
Recombinant Human Epidermal Growth Factor Precursor Is a
Glycosylated Membrane Protein with Biological Activity
- The Nobel Foundation 1986
The Nobel Prize in Physiology or Medicine 1986 was awarded jointly to Stanley Cohen and Rita Levi-Montalcini “for their discoveries of growth factors”
BLUE GREEN ALGAE EXTRACT (AFA) Promotes cellular proliferationAphanizomenon flos-aquae (AFA) has been shown to stimulate human stem cell recruitment, migration and proliferation. The most nutrient rich and bio-active algae known, full of minerals, vitamins, enzymes, chlorophyll, amino acids, nucleic acids, fatty acids, and DHA. Due to the algae’s nutritious soft cell wall, these nutrients are readily available to the body. Note: AFA is different than spirullina or chlorella.
- Med Sci Monit. 2010 Jan;16(1):BR1-5.
Effects of blue-green algae extracts on the proliferation of human adult stem cells in vitro: a preliminary study
- Cardiovasc Revasc Med. 2007 Jul-Sep;8(3):189-202.
Mobilization of human CD34+ CD133+ and CD34+ CD133(-) stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae–related to modulation of CXCR4 expression by an L-selectin ligand?
CAVIAR EXTRACT Collagen enhancer and Proteins cross linking inhibitorCaviar extractwas found to speed up the natural production of collagen up to 67%and significantly reduces the protein cross linking (fibronectin). It contains a wealth of vitamins and minerals to nourish the skin and reduce the signs of aging. Caviar is very rich in vitamins (especially vitamin A, group B, D, and E), oligo elements (sodium, potassium, calcium, magnesium, phosphorus, iron), micro-elements (Co, Cu, P, Si) proteins and amino acids. It has moisturizing and emollient properties and it’s use is highly recommended for aged and wrinkled skin.
SOY PHYTO PLACENTA EXTRACTReduces wrinkles, restores youthful collagen type IIIAlso known as Cleopatra’s Secret is rich in protein, amino acids. Soy phyto placenta reduces wrinkles and promotes an even complexion. It is used because it is virtually bio-identical to human placenta. Completely plant-based placental extract has the same anti-aging and repairing benefits as human placental proteins. Restores Youthful Collagen Type III.
ARGANIA SPINOSA KERNEL OIL (ARGAN OIL) Skin conditioner, anti-oxidant, anti-microbialLong prized in the Middle East as a beauty secret, Argan oil has numerous skin enhancing properties including free radical protection, antimicrobial and moisturizing properties and scar reduction.
- J Cosmet Dermatol. 2007 Jun;6(2):113-8.
Clinical and instrumental study of the efficacy of a new sebum control cream.
- Crit Rev Food Sci Nutr. 2010 May;50(5):473-7. doi: 10.1080/10408390802544520.
Should the amazigh diet (regular and moderate argan-oil consumption) have a beneficial impact on human health?
COMMIPHORA MYRRHA OIL (MYRRH) Analgesic, anti-septic, immune modulatorSpanning several millennia, Myrrh has been used for skin and medicinal purposes since the ancient Egyptians. Now it is highly prized for its remarkable anti-septic, analgesic and immune effects. Myrrh has been shown to have anti-bacterial effects primarily by improving antigen response. It may also have anti-tumor activity. In RG-Cell Myrrh is primarily used to reduce inflammation and “clean” the skin of unwanted pathogens that may contribute to acne, blemishes or scar formation.
- J Immunotoxicol. 2010 Mar;7(1):68-75. doi: 10.3109/15476910903409835.
Effect of myrrh (Commiphora molmol) on leukocyte levels before and during healing from gastric ulcer or skin injury.
- Holist Nurs Pract. 2007 Nov-Dec;21(6):308-23.
Myrrh: medical marvel or myth of the Magi?
- J Egypt Soc Parasitol. 2008 Dec;38(3):763-96.
An update review on Commiphora molmol and related species.
MELALEUCAALTERNIFOLIA (TEA TREE) LEAF OIL Wound healing, anti-oxidant, anti-bacterial, anti-fungalFrom the native Australian Melaleuca plant, Tea Tree oil has prized effects on the skin including immune modulation, anti- microbial and antifungal activity. It is especially effective against yeast species and acne vulgaris. The Australian Army puts it in soldiers’ kits to help heal cuts and scrapes and prevent fungal infections.
- Int J Dermatol. 2012 Sep 24. doi: 10.1111/j.1365-4632.2012.05654.x.
A review of applications of tea tree oil in dermatology.
- BMC Infect Dis. 2006 Nov 3;6:158.
In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species.
- J Dermatol Sci. 2012 Aug;67(2):120-9. doi: 10.1016/j.jdermsci.2012.05.005. Epub 2012 May 27.
Topically applied Melaleuca alternifolia (tea tree) oil causes direct anti-cancer cytotoxicity in subcutaneous tumour bearing mice.
- Front Microbiol. 2012;3:220. doi: 10.3389/fmicb.2012.00220. Epub 2012 Jun 18.
Antifungal, cytotoxic, and immunomodulatory properties of tea tree oil and its derivative components: potential role in management of oral candidosis in cancer patients.
ROSA CANINA SEED EXTRACT (ROSE HIP OIL) Wound healingRose hip oil is effective on scars caused by acne, surgery, burns, chicken pox, injuries and cuts. It not only remodels damaged skin structure, it also improves skin color and elasticity. Rose hip oil halts and reverses typical signs of aging like wrinkles, crow’s feet and sagging skin by accelerating the skin’s cellular activity to improve skin renewal and cell regeneration. Rose hip oil restores the optimal balance of fatty acids and water which re-hydrates the skin.
ROSE FLORAL WATERSkin emollient, healing and hydration agentRose water and its attendant oil have been shown to improve skin moisture and hydration, skin smoothness and improve the differentiation of epidermal keratinocytes while restoring skin barrier functions.
- Skin Pharmacol Physiol. 2011;24(6):289-93. doi: 10.1159/000329214. Epub 2011 Jun 25.
Dermocosmetics for dry skin: a new role for botanical extracts.
- Ann Dermatol. 2010 Aug;22(3):255-61. doi: 10.5021/ad.2010.22.3.255. Epub 2010 Aug 5.
Enhancement of keratinocyte differentiation by rose absolute oil.
LEVULINIC ACID Strong antimicrobial, skin conditionerProduced from recombinant vegetable sources. Classified in the EU as a skin conditioner and while used in perfumes, it also has strong antimicrobial properties. Sustainably sourced and non-sensitizing, levulinic acid has been chosen as a suitable non-toxic antimicrobial and extends product shelf life.
ADENOSINEAnti-oxidant, Anti-Aging, Cellular MessengerAdenosine penetrates deeply into the skin to help prevent wrinkles, reduce UV B sun damage. It is particularly effective for peri orbital wrinkles (crow’s feet) and glabellar (forehead) frown lines. It has been shown to enhance the effects of Botox in facial wrinkle reduction. RG-Cell uses Adenosine delivered in a Lecithin based “Adenosome” for enhanced deep epidermal and dermal delivery
- Journal of Investigative Dermatology, Volume 124, Issue 4, April 2005, pages 756-763
- Journal of Cutaneous Medicine and Surgery, Volume 8, Issue 2, March-April 2004, pages 90-96
- Int J Cosmet Sci. 2006 Dec;28(6):447-51. doi: 10.1111/j.1467-2494.2006.00349.x.
Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS technique.
- J Cosmet Sci. 2007 Mar-Apr;58(2):147-55.
Formulation, characterization, and efficacy of an adenosine-containing dissolvable film for a localized anti-wrinkle effect.
- Arch Dermatol Res. 2008 Oct;300(9):485-93. doi: 10.1007/s00403-008-0882-x. Epub 2008 Aug 30.
Effects of adenosine 5′-monophosphate on epidermal turnover.
CITRUS AURANTIUM DULCIS (ORANGE, NEROLI) Skin circulatory agent, anti-microbialSourced from the Bitter Orange Tree Flowers, Neroli is often used in perfumes for its pleasant scent. It has also found a home in aromatherapy where it has been studied for its calming effects. But it also has circulatory stimulation properties, anti-microbial effects and anti-oxidant.
- Nat Prod Commun. 2011 Jul;6(7):1009-14.
Composition of Egyptian nerolì oil.
HYALURONIC ACID Anti-wrinkle, anti-aging, skin softner, delivery agentInjectable Hyaluronic Acid has achieved super star status as a dermal filling agent. But the topical form also has amazing properties including, skin structural support which makes the skin look softer and fuller. Due to RG-Cells patented double layer delivery technology this agent is released at the deep epidermal and dermal level in many ways mimicking the action of injectable agents with daily use.
- J Invest Dermatol. 2013 Mar;133(3):658-67. doi: 10.1038/jid.2012.364. Epub 2012 Oct 25.
Enhancing structural support of the dermal microenvironment activates fibroblasts, endothelial cells, and keratinocytes in aged human skin in vivo.
- Arch Dermatol. 2007 Feb;143(2):155-63.
In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin.
- J Clin Aesthet Dermatol. 2012 Oct;5(10):20-3.
Efficacy and safety of a low-molecular weight hyaluronic Acid topical gel in the treatment of facial seborrheic dermatitis.
LAVANDULA ANGUSTIFOLIA (LAVENDER) OIL Healing agent, anti-septic, anti-fungalFirst documented in Roman Times, Lavender Oil is another skin active oil that has centuries of use behind it. It has many popular uses including cleaning and treating minor skin abrasions and bites because of its healing properties
- Nat Prod Commun. 2012 Oct;7(10):1401-4.
Antimicrobial activity of blended essential oil preparation.
- Nat Prod Commun. 2012 Oct;7(10):1393-6.
Composition and antipseudomonal effect of essential oils isolated from different lavender species.
TETRAHYDROPIPERINE (COSMOPERINE) Permeability enhancer, improves nutrient deliveryCosmoperine, also known as tetrahydropiperine (THP), is derived from piperine, the active principle of black peppercorns (Piper nigrum) which acts as a penetration enhancer when added to water soluble ingredients. It works by enhancing the bioavailability of nutrients, including vitamins, minerals, coenzymes, and nutraceutical herbal extracts. Its effects are further enhanced by RG-Cell’s double Layered Encapsulation Technology.
- Zutshi, U. et al. (1984). J. Assoc. Physicians of India. 33:223-224
- Zutshi, U. et al. (1989) Indian Patent # 1232/DEU89
- Bano, C.K. et al. (1991) Eur. J. Clin. Pharm. 41:615-618
- Atal, C.K. et al. (1977) Indian J. Exp. Biol. 15:1230-1232
- Majeed, M. et al. US Patent #5,536,506 (1996), US Patent # 5,744,161 (1998), US Patent # 5,972,382 (1999), US Patent # 6, 054, 585 (2000) and International patents
- Zhong Yao Cai. 2005 Jul;28(7):570-4.
Study on proliferation effect of extracts of Piper longum on mesenchymal stem cells of rat bone marrow and the relationship to chemical functional groups.
TOCOPHEROL (VITAMIN E) Anti-oxidant, moisturizingVitamin E is necessary for the efficient utilization of oxygen in the tissues and for maintenance of connective tissues. As a strong intracellular and intercellular antioxidant agent, Vitamin E Oil protects fats from breakdown by free radical chain reactions. It also contributes to the stability of biological membranes and promotes intracellular respiration. It can provide moisture, protection, and healing. It smoothens wrinkles and cools and soothes dry irritated skin. It also helps and prevent and slow signs of ageing.
ANTHEMIS NOBILIS FLOWER OIL (CHAMOMILE OIL) Anti-inflammatoryGerman Chamomile is often found in cosmeceuticals designed to fight acne because of its anti-septic and cleansing properties. In addition it reduces redness and swelling through immune modulation. It also speeds wound healing.
- Molecules. 2010 Oct 27;15(11):7532-46. doi: 10.3390/molecules15117532.
Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model.
- Nat Prod Res. 2010 May;24(8):697-702. doi: 10.1080/14786410701654875.
Evaluation of topical Matricaria chamomilla extract activity on linear incisional wound healing in albino rats.
- J Vet Sci. 2010 Mar;11(1):35-41.
Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice.